You are here:

IMPROVED Methyl Factors

IMPROVED Methyl Factors

OFFER > Buy 2 Get 1 FREE - Add 2 to the basket - Get 1 Free (of the same product)

Double click on above image to view full picture

Zoom Out
Zoom In

IMPROVED Methyl Factors

Improved Methyl Factors has been developed to help support those who need extra methyl donor nutrients to facilitate the methylation process in the body. Methyl groups are the body’s messengers; they join with other compounds to “jump-start” reactions, such as turning on or off a gene, or activating an enzyme.
Size: 60 Capsules
Product Code: 2214

In stock


Free delivery on UK orders over £25. All prices shown inclusive of VAT, except where stated. Place order before 12pm and we will despatch your order the same day.

Tell your friends:

Facebook Twitter Email a friend


Improved Methyl Factors has been developed to help support those who need extra nutrients to facilitate the methylation process in the body. 100mg of vitamin B1 in the form of benfotiamine has been added to improve the formula. Benfotiamine is lipid-soluble (so is more bioavailable and effective than thiamine) making it potentially better suited to those who smoke or drink alcohol. Benfotiamine is also a potent antioxidant and essential for energy metabolism.

Methyl Factors also contains TMG (Trimethylglycine) known as betaine, vitamin B6 (as pyridoxal-5-phosphate), folic acid (as L-Methylfolate), vitamin B12 as methylcobalamin and vitamin B2 (riboflavin 5-phosphate) - all of these nutrients can donate methyl groups. The mineral zinc is also included in the formula. All of these ingredients also support the nervous system and detoxification pathways in the body. Only recommended for use under the guidance of a practitioner.

  • TMG, vitamin B6, vitamin B12 and methylfolate collectively provide a full spectrum of methyl donor nutrients
  • TMG is the best methyl donor. It is not the same as betaine HCL, which is not necessarily a methyl donor but is sometimes used erroneously for this purpose. Many diets are low in betaine from food sources
  • B vitamin deficiency is all too common, and this is another reason for shortage of methyl donor nutrients in diet
  • Zinc has been added to help protect and support those who drink alcohol regularly
  • This formula comprises folic acid as methylfolate as it is the most stable, safe and bio-effective supplemental form of folate and the only form useful to people with impaired methylation
  • This formula includes vitamin B6 in the form of pyridoxal-5-phosphate, the bio-active and enzymatically converted form of B6. There is evidence to show that some people with high homocysteine, for instance, and impaired methylation, lack the enzyme necessary to convert pyridoxine (the other supplement form of B6) to its metabolically active form
  • This supplement includes vitamin B12 as methylcobalamin, the most bio-effective form. Some vitamin B12 products on the market are cyanocobalamin which needs to be enzymatically converted to methylcobalamin in the body
  • Folate, vitamin B12, betaine and vitamin B6 all have the permitted health claim of ‘contributing to normal homocysteine metabolism’ 

IMPROVED Methyl Factors 1 capsule will provide on average:

Active Nutrient Strength %NRV*
Vitamin B1 (as benfotiamine) 100.0mg 9090
Trimethylglycine 400.0mg *
Vitamin B2 (riboflavin 5-phosphate) 3mg 214
Vitamin B6 (as pyridoxal-5-phosphate) 15mg 1071
Folic Acid (as methylfolate) 800µg 400
Vitamin B12 (as methylcobalamin) 1000µg 40,000
Zinc 5mg 50

+NRV = Nutritional Reference Value
* Indicates no NRV


Trimethylglycine (TMG, also known as betaine), vitamin B1(as benfotiamine), vitamin B6 (as pyridoxal-5-phosphate), zinc citrate, Vitamin B2 (riboflavin 5-phosphate), vitamin B12 (as methylcobalamin), folic acid as (5-methyltetrahydrofolate), silicon dioxide, maltodextrin, stearic acid, HPMC (vegetable cellulose, capsule shell).

Suggested Intake:

One capsule daily with food as a food supplement as directed by a practitioner, only recommended for use under the guidance of a practitioner.

Suitable for:

Vegetarians and vegans, and for people with Candida and yeast sensitivities.


Pregnant or breastfeeding women should consult their doctor before taking this product. Long term daily use of 10mg or more of vitamin B6 may lead to mild tingling and numbness

Non-Active Ingredients:

Silicon dioxide, maltodextrin, stearic acid, HPMC (vegetable cellulose, capsule shell).

Non GM & Free From:

Wheat, yeast, starch, gluten, lactose, added sugars, colourings, flavourings & preservatives.


Keep cool, dry & out of direct sunlight. One of the ingredients in this product attracts moisture, which overtime will degrade it. When this happens it turns orange and goes hard. To avoid this, the product should be kept in the pot provided and the lid closed. These capsules should not be stored in daily pill boxes for longer than 48 hours.

Keep all supplements out of sight and reach of young children. Do not exceed stated recommended intake. Food supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Adverse reactions to supplements are rare, but If you experience an adverse reaction stop taking the product and contact your practitioner or one of our nutritional therapists. Sometimes a supplement will suit one person but not another.

  • 15-Aug-2019

    Seems to be a great product
  • 12-Apr-2019

    The Methyl Factors really works in lowering my homocysteine. Ever since taking it my homocysteine has decreased from 20.2 umol/L in 2016 to 8.15 umol/L in 2019. I don't take it daily as recommended because it resulted in too high serum vitamin B12. I take it three times a week with one capsule each time...
    Read More
  • 23-Mar-2019

    I think that the Methyl Factors have had a beneficial effect on my heart rate and blood pressure
  • 08-Mar-2019

    I have been using Methyl factors for a few years and credit it with bringing my Homocysteine down from 19.90 to 11 .20
  • 15-Sep-2017

    Attractive packaging, and the capsules are easy to swallow. There's a good amount of capsules in the bottle, so you're not continually having to order more all the time.
  • 02-Aug-2017

    High quality formulation using methylated B vitamins
  • 26-Jul-2017

    Also bought Magnesium Threonate as suggested by nutritionist. This, along with other dietary recommendations, all seems to be working!

    Our Response:

    Hi - pleased to hear the advice and support from our nutritional therapist was helpful.

    Best wishes-
  • 28-Jun-2017

    appears good, hopefully does what it says on the pot!
  • 07-Apr-2017

    I have not been using long enough to rate .
  • 31-Mar-2017

    Don't know results yet. The pill is easy to swallow and easily digestible.
  • 14-Feb-2017

    Ottimo venditore, buon prodotto
  • 08-Jan-2017

  • 02-Dec-2016

  • 02-Dec-2016

    As Above
  • 25-Nov-2016

    As Above
  • 21-Oct-2016

    I am putting 'Good' because it isn't bad but so far (about a month in) has not had the desired effect on the condition I am trying it for, which is misophonia (a psycho-neurological sensory processing disorder). However, this is not the condition that Cytoplan is marketing it for, so I am not going to...
    Read More

    Our Response:

    If the problem is caused at least in part due to hypomethylation then this product should help you. But if you do not get the desired result, because this type of problem can be complex please do feel able to contact me directly as with a little more information I might be able to offer more tailored...
    Read More
  • 01-Oct-2016

    The tablets are very difficult to swallow , we would prefer it to be in capsules

    Our Response:

    Thank You for your comment. The tablets are indeed quite large as this appeared the best way of getting all that was needed in a dose into one tablet. But I am presently looking at the feasibility of encapsulating the ingredients- however it would be a 2 capsule dose as tabletting has the advantage of...
    Read More
  • 27-Sep-2016

  • 25-Aug-2016

    Contents good but glad to see on the website that pill size is being reduced. Once spent a very unpleasant night with a pill half-swallowed, unable to make it go up or down, despite water, bread, whatever else I could think of, and was left with a bruised throat for a few days. Shame when the contents...
    Read More
  • 25-Aug-2016

  • 20-Aug-2016

    As Above
  • 20-Aug-2016

    As Above
  • 03-Aug-2016

    Taking it to help with the MTHFR gene defect, haven't noticed much yet as it has only been a few weeks, although my hair loss (female, still investigating the cause) seems to have calmed down.
  • 03-Aug-2016

    Great value offer!
  • 03-Jul-2016

    The tablets can sometimes be a little hard to swallow as they are quite "dry". I started taking them on the advice of my homeopath to help get me into a good state in readiness for surgery and radiotherapy for cancer which has been successfully treated. I am continuing with them in the hope of...
    Read More

    Our Response:

    I do understand that these are quite large tablets and can be difficult for some people to swallow. Mindful of this the next batch will contain slightly smaller tablets which I hope will be easier for you and others to swallow. We have reduced the TMG slightly, which will not affect efficacy but will...
    Read More
  • 21-Mar-2016

    awesome products
  • 10-Feb-2016

    as above
  • 02-Oct-2015

    Has really helped support my liver
  • 21-Jun-2015

    Having discovered a genetic problem with methylation, I found this supplement and it has worked extremely well for me. Taking it seems to help me get the most of all my other supplements, improve my energy and immune system, and generally lead me to better health. There are other methylation...
    Read More
  • 15-Mar-2015

    excellent product
  • 15-Mar-2015

  • 26-Feb-2015

  • 26-Feb-2015

    I don't know yet. Have been taking the tablets for a couple of weeks but it is difficult to know if my energy levels are improving or not. I think it is too early to judge.
  • 06-Dec-2014

    A high quality product.
  • 04-Dec-2014

    Excellent product
    Highly recommended
  • 27-Oct-2014

    A DNA health test showed weak methylation process, so therefore I tried out this product Methyl Factors (2212). However, I feel that it leaves so much pain in my stomach and gut, and it feels as if this compact tablet cannot be dissolved in my digestive system at all and therefore only creates more...
    Read More

    Our Response:

    Methyl factors breaks down very easily indeed. In fact if it is left in the atmosphere for long it starts to break down - so this is not the reason for the problem you are experiencing. It could be that you need some expert help with this as it is quite complex. Even for those with methylation issues,...
    Read More
  • 03-Sep-2014

    Only just started using this product but it's a brilliant combination for anyone with methylation issues.
  • Show all reviews

    For UK-delivered orders that are under £25.00, we charge a nominal postage and packing fee of £1.95. UK orders above £25.00 are DELIVERED FREE OF CHARGE. 

    Dependent on weight, your order will either be sent by First Class post (Royal Mail) or via our nominated courier. A signature is required on receipt of the goods if delivered by our courier. 

    Please check all requirements (import taxes, customs regulations etc) regarding deliveries to countries outside the UK. Cytoplan Ltd cannot be held responsible for parcels that do not comply with the import regulations of the desination country.

    We cannot guarantee next day delivery, although you should receive your order within 2-3 working days. 

    If you have not received your order within 5 working days, please contact our Customer Services department.

    1. You can email our Customer Service department via our contact form here. 
    2. You can telephone on +44(0)1684 310099 
    3. You can write to us at Cytoplan Ltd, Unit 8 Hanley Workshops, Hanley Road, Hanley Swan, Worcester. Worcestershire.WR8 0DX


    You may also be interested in...

    In stock

    Vitamin B6 (Pyridoxal-5-Phosphate)

    Pyridoxal 5 Phosphate is the metabolically active form of vitamin B6 - vital for ...

    Size:60 Tablets
    Full details

    In stock

    Methylfolate Supplement (Folic Acid)

    Our Methylfolate supplement contains 400ug of Methylfolate per capsule in a base of ...

    Size:60 Capsules
    Full details

    In stock

    COQ10 Multi

    CoQ10 Multi is our most comprehensive Wholefood multivitamin and mineral formula ...

    Full details