Which form of B12 is best?

Q: What form of B12 is best?   

Vitamin B12 is used in the metabolism of every cell in the human body. It contributes to normal nervous system functioning through its role in the synthesis of myelin (the fatty layer which surrounds our nerve cells); supports the maturation of red blood cells in bone marrow, as well as acting as a cofactor in fatty acid and amino acid metabolism and DNA synthesis. For this reason, deficiency can lead to widespread signs and symptoms, including:

  • Pale skin
  • Weakness, fatigue and light-headedness
  • Nerve issues like tingling, numbness and muscle weakness
  • Impaired vision
  • Hormonal and mood imbalances
  • Sleep disturbance
  • Cognitive impairment
  • Problems with balance

The absorption and synthesis of B12 in the body is a highly complex process and consequently low levels can often be observed even when there is adequate dietary intake. Some factors which can contribute to low B12 status include:

 

  • Age - low levels being common among the senior population
  • Vegan and vegetarian diets - B12 is primarily bound to animal protein
  • GI factors – such as low stomach acid and damage to the small intestine (for example in inflammatory bowel conditions and coeliac disease)
  • Genetics
  • Medication

While the synthetic cyanocobalamin has historically been the chief form of B12 used both medically and commercially, it is an inactive form which needs to go through 4 metabolic steps before it can be used by the body, and this conversion can be ineffective in some people.

Cytoplan’s Vitamin B12 Sublingual contains the two natural, active forms of the vitamin: methylcobalamin and adenosylcobalamin, both of which are readily available to be used by the body. The body can also convert each into the other form depending upon need.

Methylcobalamin is needed for several functions such as the methylation cycle and lowering levels of homocysteine, as well as having a neuroprotective function, promoting myelin sheath restoration, and having a positive effect on nerve action and restoration. 

Adenosylcobalamin, often referred to as the “mitochondrial B12” is involved in the Kreb’s cycle and the production of cellular energy, as well as being the main building block of the MUT enzyme; a crucial element for the metabolic process that provides energy to our body. This form of B12 is also required to reduce levels of methylmalonic acid, which can cause nerve damage at high levels as well as playing a role in the catabolism of various important amino acids and hormones. Adenosylcobalamin is a good form to consider in cases of chronic exhaustion, muscle weakness, liver damage and hepatitis, where low B12 is suspected.

Cytoplan also offers a Vitamin B12 hydroxocobalamin. The Hydroxocobalamin form of B12 is one of the predominant forms found in food. While it is an inactive form of B12, it has been found to raise levels of B12 in the blood stream for a much longer time than cyanocobalamin. Hydroxocobalamin can be converted into methylcobalamin by the body and can be important to begin with if one has both a folate and a vitamin B12 deficiency to prevent damage to the central nervous system. Hydroxocobalamin can convert to multiple forms and therefore has multiple purposes, including detoxification and inhibiting nitric oxide, which can cause oxidative stress.

Recommended Products
  1. image of vitamin b12 pot - containing b12 methylcobalamin and adenosylcobalamin
    Feefo Product Rating 4.7 out of 5 with 252 reviews
    In stock
    Vitamin B12 sublingual

    A high potency active B12 supplement containing a combined dose of 1mg of met...

    £9.40
    Full Details
  2. image of vitamin b12 hydroxocobalamin recyclable pot
    Feefo Product Rating 4.7 out of 5 with 90 reviews
    In stock
    Vitamin B12 Hydroxocobalamin Tablets

    Cytoplan's vitamin b12 hydroxocobalamin supplement is at a high potency of 1...

    £10.90
    Full Details
  3. Multi B Extra
    Feefo Product Rating 4.8 out of 5 with 204 reviews
    In stock
    Multi B Extra

    This Food State supplement contains all of the essential B vitamins at around...

    £21.80
    Full Details
21 September 2021
345 view(s)

You have been referred by a friend and you're one step away from your £10 reward.

All you need to do is create an account on our site and you will be given 1000 reward points for a £10 discount voucher.

Once you have placed your first order, the friend who referred you will also be rewarded!

*Referrals will only be deemed successful for new customers. Existing customers not eligible.

mc_vrt_rgb_pos image/svg+xml
© Copyright Cytoplan Ltd - (Company Reg No: 01493205)