According to the British Thyroid Foundation, 1 in 20 people in the UK suffer from thyroid disorders.

However, Thyroid UK believes that the incidence is much higher due to undiagnosed hypothyroidism.  This blog discusses how thyroid hormone conversion can become compromised and examine some of the causes that lead to low active thyroid levels.  Finally, we will offer some solutions to help improve thyroid hormone conversion.

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Basic Thyroid Physiology

The thyroid is a vitally important hormonal gland and considered the thermostat of the body.  It plays a major role in the metabolism, growth and maturation of the human body, helping to regulate many body functions by constantly releasing a steady amount of hormones into the bloodstream. Every cell in the body depends upon thyroid hormones for regulation of its metabolism.

Hypothalamic–pituitary–thyroid axis

The process of thyroid hormone synthesis and secretion is regulated by a negative feedback loop and this process depends upon:

• the hypothalamus - a region of the brain responsible for monitoring messages from the nervous and endocrine systems
• the pituitary gland - often called the master gland because it controls a number of hormone glands in your body, including the thyroid and adrenals, the ovaries and testes
• the thyroid gland - butterfly-shaped organ located in the base of your neck. It stores and produces hormones that affect the function of virtually every organ in our body

When the hypothalamus senses low circulating levels of thyroid hormone (triiodothyronine T3 and thyroxine T4, it responds by releasing thyrotropin-releasing hormone (TRH). TRH stimulates the pituitary to produce thyroid-stimulating hormone (TSH).

TSH, which talks directly to the thyroid gland itself causes iodine to enter the thyroid, and turns on an enzyme called thyroid peroxidase (TPO). Thyroid cells combine iodine and the amino acid tyrosine to make:

• T3 = bioactive hormone - named for its three molecules of iodine
• T4 = prohormone - named for its four molecules of iodin

This feedback loop continues until levels in the blood return to normal.

Approximately 100μg of thyroid hormones are secreted from the gland each day mostly in the form of T4 with about 10% as T3.⁽¹⁾

80% of T4 undergoes peripheral conversion to the more active T3, which is approximately 5 times more biologically active than T4.

T4 is converted into the more active T3 by the deiodinase system (D1, D2, D3) mainly in the liver, gut, brain, skeletal muscle and the thyroid gland itself.

T4 circulates through to the liver where 60% of it is converted into T3 through the glucuronidation and sulphation pathways during phase II of detoxification.⁽²⁾ Another 20% is converted into reverse T3 (rT3) which is permanently inactive.  rT3 is essentially the opposite of T3, specifically designed to balance out levels of T3 in the body. The final 20% is converted into T3 sulphate and T3 acetic acid which can then be further metabolised by healthy gut bacteria to produce more active T3.⁽³⁾

TSH is Normal!

Frequently people experience common hypothyroid symptoms but lab results are normal. Symptoms normally present as fatigue, brain fog and memory issues, cold hands and feet, hair loss, depression, constipation, difficulty sleeping and muscle weakness or joint pain and more.  This common problem may be caused by poor thyroid hormone conversion and is explained below:

How is T4 Converted to T3?

Reactions that catalyse the conversion of thyroid hormones are triggered by enzymes called deiodinases which come in 3 forms:

• deodinase type I (D1) converts inactive T4 to active T3 throughout the body. D1 can be suppressed and down-regulated in response to stress, liver dysfunction, insulin resistance, inflammation, gut dysbiosis, etc.
• deodinase type II (D2) is 1,000 times more efficient at converting T4 to T3 than D1 in the rest of the body. D2 also has an opposite response from that of D1 to physiologic and emotional stress etc. D2 is stimulated and up-regulated in response to such conditions.
• deodinase type III (D3) converts T4 to rT3 and competes with D1. rT3 is up-regulated during chronic physiologic stress and illness.

Deiodinase enzymes are essential control points of cellular thyroid activity that determine intracellular activation and deactivation of thyroid hormones. Most of the "deiodination" occurs in the liver, kidney and thyroid gland.

So let’s now look into some of the causes that lead to a low peripheral T3 level.

Stress

Chronic physical, psychological or environmental stress results in decreased D1 activity⁽⁴⁾ and an increase in D3 activity⁽⁵⁾ decreasing thyroid activity by converting T4 into rT3 instead of T3. rT3 is inactive and it functions to slow the body down which is necessary in times of stress or trauma for the body to heal.  Conversely, D2 is stimulated, which results in increased T4 to T3 conversion in the pituitary and reduced production of TSH.

Therefore, stress management and adrenal support is vital when supporting the thyroid.  You may be interested in our blog on the science of stress and resilience.

Insulin Resistance/Diabetes

It has been shown in a number of studies that insulin resistance, diabetes, or metabolic syndrome have associated significant reduction in T4 to T3 conversion, an intracellular deficiency of T3, and an increased conversion of T4 to rT3, further reducing intracellular T3 levels.⁽⁶⁾⁽⁷⁾

Iron/Selenium/Zinc deficiency

Iron deficiency has been shown to significantly reduce T4 to T3 conversion, increase rT3 levels, and block the thermogenic (metabolism boosting) properties of thyroid hormone.⁽⁸⁾⁽⁹⁾

Selenium is a fundamental component of various seleno-proteins, molecules essential to the body’s ability to create and use thyroid hormones. It plays a role in maintaining thyroid health since it works together with iodine and is required to produce T3. Low levels of selenium inhibit conversion of thyroid hormones into the form that is required by the cells and can result in increased rT3.⁽¹⁰⁾

Zinc plays a role in the functioning of the immune system and it may play a role in thyroid hormone metabolism in low T3 patients and in part contribute to conversion of T4 to T3.^(11)(12) In addition a deficiency in zinc⁽¹³⁾ can also drive up rT3 levels.

Furthermore, it is interesting to note that researchers have found that the nutritional zinc status in obese and diabetic subjects is altered: low zinc concentrations in plasma and erythrocytes with high urinary zinc excretion has been reported in obese children and adolescents.⁽¹⁴⁾ 

Chronic Illness/Inflammation

The inflammatory cytokines IL-1, Il-6, C-reactive protein (CRP), and TNF-alpha will significantly decrease D1 activity and reduce tissue T3 levels. Studies have shown that these inflammatory cytokines affect thyroid hormone conversion, reducing T4 conversion to T3 and also increasing rT3. This leads to reduced T3 and therefore increased incidence of under-active thyroid conditions.

Gut Dysbiosis

Another factor that can affect thyroid hormone conversion is poor gut health, also known as dysbiosis. Gut imbalances include: small intestinal bacterial overgrowth, reflux/GORD, yeast overgrowth, history of chronic antibiotic use and inflammatory bowel disease.

One role of the gut bacteria is to assist in converting inactive T4 into T3. As mentioned earlier approximately 20% of T4 is converted to T3 in the digestive tract, in the forms of T3 sulphate (T3S) and triidothyroacetic acid (T3AC). The conversion of T3S and T3AC into active T3 requires an enzyme called intestinal sulphatase, and intestinal sulphatase comes from beneficial gut bacteria.

Lipopolysaccharides (LPS) are present in the cell walls of gram-negative bacteria. Under normal circumstances they protect the cell membrane.  However, when gram-negative bacteria die, the LPS is released and can cause a number of problems including high amounts of inflammation and negatively affect thyroid metabolism⁽¹⁵⁾ in several ways:

• reduce thyroid hormone levels
• decrease TSH
• promote autoimmune thyroid disease (Hashimoto’s). LPS can impact deiodinase activity inhibiting the amount of T3 in circulation
• increase amounts of rT3

Inflammation in the gut also reduces T3 by raising cortisol. Cortisol decreases active T3 levels while increasing levels of rT3.⁽¹⁶⁾

 Liver Health

A sluggish liver can impact thyroid health adversely by affecting conversion of T4 to T3.⁽¹⁷⁾ This will result in lower T3 levels.  A sluggish liver could be due to liver disease, an infection like hepatitis C, alcoholism, nutrient deficiencies, methylation and glutathione problems, etc.^(18)(19)

 How to Improve Thyroid Hormone Conversion

Before beginning to work on improving thyroid conversion, it is imperative that you tackle the underlying cause. Lowering rT3 levels and increasing T3 levels is not straightforward. There are so many variables and other factors that may hamper progress. For example, if high levels of rT3 are secondary to insulin resistance and diabetes, and you don't make changes to your diet, any nutritional supplement additions may not make a difference.

​Liver Detoxification and Function

In the liver D1 is involved in converting T4 into T3 and rT3 is also broken down there, consequently liver support is essential.

There are 2 metabolic pathways in the liver that can have an impact on thyroid hormones. One of these is the glucuronidation pathway.  Glucuronidation is often involved in the xenobiotic metabolism of substances such as drugs, pollutants, bilirubin, androgens, oestrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. It has also been shown to degrade rT3. This pathway is supported by B vitamins, magnesium, and curcumin.

The second is sulphation. Sulphation involves binding things partially broken down in the liver with sulphur containing compounds. It is one of the major detoxification pathways for neurotransmitters, toxins, and hormones.  Vitamin B6 and magnesium are important for sulphur amino acid metabolism, as are foods containing sulphur such as: eggs, meat, poultry, nuts and legumes.

Another important factor is lipid peroxidation and supporting antioxidant status in the liver. Some studies have confirmed increased oxidative stress in hypothyroid states. It seems that thyroid hormones have a strong impact on oxidative stress and the antioxidant system.⁽²⁰⁾  For more information see our blog: Glutathione - The Master Antioxidant.

Adrenal Support

A few pointers are:

• avoid or minimise stimulant drinks
• stabilise blood sugar (via a moderate or low-carb diet)
• practice stress management and relaxation techniques
• make pleasure a regular part of your life

Improve Gut and Liver Health

Below are some pointers to help improve gut and liver health:

Eat plenty of fermentable fibre - Bacterial metabolites are potent endocrine modulators. When you consume fermentable fibres, your gut bacteria ferment these fibres and produce beneficial short-chain fatty acids (SCFAs).

Eat anti-inflammatory foods rich in beneficial bacteria - It has been found that beneficial microbiota will actually release anti-inflammatory messages and dampen the inflammatory response.  Foods recommended are fermented foods such as cultured vegetables, coconut water kefir, and probiotic beverages as the primary system of delivery for good bacteria.

Leafy greens and Cruciferous vegetables - Green vegetables of all kinds provide anti-inflammatory and antioxidant properties. Cruciferous vegetables such as cauliflower, cabbage, kale, broccoli and Brussels sprouts are a rich source of sulphur-containing phytochemicals called glucosinolates which offer antioxidant and anti-inflammatory properties and also support detoxification of carcinogens and other xenobiotics.

 

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If you have any questions regarding the topics that have been raised, or any other health matters, please do contact me (Jackie) by email at any time (jackie@cytoplan.co.uk) Jackie Tarling and the Cytoplan Editorial Team

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Related Cytoplan products CoQ10 Multi – This is an adult only formula and the composition includes CoQ10, Beta 1-3,1-6 Glucan and vitamins B12 and D3 meaning it is particularly suited to both men and women and those on Statin medication. It is also an excellent additional multi formula for those people taking our Red Rice Yeast Plus supplement (for cholesterol support). Ashwagandha – used in traditional Ayurverdic medicine, Organic Ashwagandha comes at a potency of 500mg per capsule. Adrenal Support – Adrenal Support comprises a blend of herbs - liquorice, ginseng and suma/pfaffia, alongside the mineral iodine and importantly, good levels of Food State™ pantothenic acid (vitamin B5). Thyroid Support – Thyroid Support has been developed to offer a Wholefood base multi mineral supplement to support thyroid health. Thyroid support contains Kelp, L-Tyrosine plus active nutrients to help ensure optimum levels of naturally-occurring thyroid hormones. Food State Selenium – Food State Selenium yeast has been documented by the European Food Standards Agency as being the safest and most bio-effective form of Selenium. Food State Selenium is far better absorbed and used (by the body) than inorganic selenium. Acidophilus Plus – Acidophilus Plus contains Lactobacillus acidophilus and a further 8 live native bacterial strains, plus a small amount of fructo-oligosaccharides (FOS).  Milk thistle – Milk Thistle capsules contain the whole herb in a powdered form, with 400mg per capsule. Tradition has recorded the use of these herbs; some being ingredients in many food recipes, others classified as medicines. Organic Kelp – Our Kelp is iodine rich and also contains a broad spectrum of minerals trace elements, micro-nutrients, vitamins, prebiotics and carotenoids.

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References

1. Nussey, S. and Whitehead, S. (2001) ‘The thyroid gland’. BIOS Scientific Publishers.
2. Amdur, R. J. and Mazzaferri, E. L. (eds) (2005) Essentials of Thyroid Cancer Management. New York: Springer-Verlag.
3. Hays, M. T. (1988) ‘Thyroid hormone and the gut.’, Endocrine research, 14(2–3), pp. 203–24.
4. CHOPRA, I. J. et al. (1975) ‘Reciprocal Changes in Serum Concentrations of 3,3′,5′-Triiodothyronine (Reverse T 3 ) and 3,3′5-Triiodothyronine (T 3 ) in Systemic Illnesses’, The Journal of Clinical Endocrinology & Metabolism, 41(6), pp. 1043–1049.
5. Bianco, A. C. et al. (2002) ‘Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases’, Endocrine Reviews, 23(1), pp. 38–89.
6. Saunders, J., Hall, S. E. H. and Sanksen, P. H. (1978) ‘Thyroid hormones in insulin requiring diabetes before and after treatment’, Diabetologia. Springer-Verlag, 15(1), pp. 29–32.
7. Islam, S. et al. (2008) ‘A comparative study of thyroid hormone levels in diabetic and non-diabetic patients.’, The Southeast Asian journal of tropical medicine and public health, 39(5), pp. 913–6.
8. Dillman, E. et al. (1980) ‘Hypothermia in iron deficiency due to altered triiodothyronine metabolism.’, The American journal of physiology, 239(5), pp. R377-81.
9. Zimmermann, M. B. and Köhrle, J. (2002) ‘The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health’, Thyroid, 12(10), pp. 867–878.
10. Gärtner, R. (2009) ‘Selenium and thyroid hormone axis in critical ill states: An overview of conflicting view points’, Journal of Trace Elements in Medicine and Biology, 23(2), pp. 71–74.
11. Nishiyama, S. et al. (1994) ‘Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency.’, Journal of the American College of Nutrition, 13(1), pp. 62–7.
12. Kandhro, G. A. et al. (2009) ‘Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous patients.’, Clinical nutrition (Edinburgh, Scotland). Elsevier, 28(2), pp. 162–8.
13. Mahmoodianfard, S. et al. (2015) ‘Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A Randomized Double-Blind Controlled Trial’, Journal of the American College of Nutrition, 34(5), pp. 391–399.
14. Marreiro, D. do N., Fisberg, M. and Cozzolino, S. M. F. (2002) ‘Zinc nutritional status in obese children and adolescents.’, Biological trace element research, 86(2), pp. 107–22.
15. van der Poll, T. et al. (1995) ‘Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man.’, The Journal of Clinical Endocrinology & Metabolism, 80(4), pp. 1341–1346.
16. Stockigt, J. R. (1997) ‘Update on the Sick Euthyroid Syndrome’. Humana Press, Totowa, NJ, pp. 49–68.
17. Nomura, S. et al. (1975) ‘Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis.’, The Journal of clinical investigation. American Society for Clinical Investigation, 56(3), pp. 643–52.
18. Imai, Y., Kataoka, K. and Nishikimi, M. (1980) ‘A possible function of thiols, including glutathione, as cofactors in the conversion of thyroxine to 3,3’,5-triiodothyronine in rat liver microsomes.’, Endocrinologia japonica, 27(2), pp. 201–7.
19. Yamanaka, T. et al. (1980) ‘Serum levels of thyroid hormones in liver diseases.’, Clinica chimica acta; international journal of clinical chemistry, 101(1), pp. 45–55
20. Petrulea, M., Muresan, A. and Dunce, I. (2012) ‘Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism’, in Antioxidant Enzyme. InTech.